원광대 분자면역학 면역관용과 mtor ppt발표자료

목차

1. Immunological tolerance
2. Regulatory T cell(Treg)
3. Foxp3의 발현
4. mTOR
5. Foxp3와 Treg
6. 최근 연구동향

본문내용

면역관용
Immunological tolerance
Central tolerance
림프구 전구세포→ 미성숙 림프구-자가항원 인식
→조절 T 림프구의 발달 (CD4⁺ T 세포만)
→수용체의 변화(수용체 편집; B세포)
→세포자멸사 (결실)

Peripheral tolerance
성숙림프구
자가항원 인식
→ 억제
→ 세포자멸사(결실)
→ 무반응

Immunological tolerance
특정 조건에서 항원과 접촉한 동물이 동일 항원에 반응하지 않고 내성을 갖는다는 말(정상적인 개체는 자가항원에 대해 관용을 가진다.)

참고자료

· http://m.bdbiosciences.com/kr/research/tcell/regulatorytcells/workflow/index.jsp
· http://tcell.snu.ac.kr/Regulatorytcell
· https://www.thermofisher.com/kr/ko/home/life-science/cell-analysis/cell-analysis-learning-center/cell-analysis-resource-library/ebioscience-resources/t-regulatory-cells-overview.html#/legacy=ebioscience.com
· https://www.slideshare.net/AllergyChula/immunological-tolerance-70056314?qid=d2b4ab96-50de-461a-af6a-34b5a9009879&v=&b=&from_search=2
· http://m.cafe.naver.com/idoctorplus/387
· https://www.cellsignal.com/contents/science-pathway-research-pi3k-akt-signaling-resources/mtor-signaling-pathway/pathways-mtor-signaling
· 최신면역학(미생물, 면역분과학회) 라이프사이언스 p..231-249
· Cellular and Molecular Immunology 8th edition ELSEVIER p.-359-386
· Regulation and function of mTOR signalling in T cell fate decision
· Hongbo Chi Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA, Published in final edited form as: Nat Rev Immunol . ; 12(5): 325–338. doi:10.1038/nri3198
· Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol. 2011; 12:21–35. [PubMed: 21157483]
· Thomson AW, Turnquist HR, Raimondi G. Immunoregulatory functions of mTOR inhibition. Nat Rev Immunol. 2009; 9:324–337. [PubMed: 19390566] 3. Araki K, Ellebedy AH, Ahmed R. TOR in the immune system. Curr Opin Cell Biol. 2011
· Iwasaki A, Medzhitov R. Regulation of adaptive immunity by the innate immune system. Science. 2010; 327:291–295. [PubMed: 20075244] 6. Delgoffe GM, et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity. 2009; 30:832–844. Provides the first genetic evidence for mTOR in promoting CD4+ effector T cell differentiation while inhibiting induction of TReg cells. [PubMed: 19538929]