[한의학,침구과학] 침의 면역학적기전
*순*
다운로드
장바구니
목차
1. 소개2. 침 자극에 의한 NK cell 의 활성도 증가
3. 침 자극에 의한 Th1/2 cell 관련 면역조절
4. 침 자극에 의한 신경 - 면역 상호작용
5. 결론
본문내용
침 자극에 의한 NK cell의 활성도 증가- 1. NK cell은 tumor cell과 virus-infected cell을 처리한다.
■ NK cell의 기능
▪ apoptpsis 유도
- 종양세포의 apoptosis : Fas (CD95)–Fas ligand (CD95L) interaction으로 종양세포의 apoptosis
- ADCC(Antibody-dependent cell-mediated cytotoxicity) 작용 : 항체로 옵소닌된 표적세포의 apoptosis 유발
▪ cell lysis
- perforin과 granzyme 단백분해효소
- virion의 release
▪ cytokine 생산과 종양세포 감시
- 대식세포의 활성화 : IFN-γ
- 종양세포의 apoptosis 유발 : TNF-α
참고 자료
xi) Park, M.B., Ko, E., Ahn, C., Choi, H., Rho, S., Shin, M.K., Hong, M.C., Min, B.I., Bae, H., 2004. Suppression of IgE production and modulation of Th1/Th2 cell response by electroacupuncture in DNPKLH immunized mice. J. Neuroimmunol. 151, 40 44.xii) Kim, S.K., Lee, Y., Cho, H., Koo, S.T., Choi, S.M., Shin, M.K., Hong, M.C., Min, B.I., Bae, H., 2009. A parametric study on the immunomodulatory effects of electroacupuncture in DNPKLH immunized mice. Evid. Based Complement. Alternat. Med.
xiii) 김정신 외, 足三里 電鍼刺戟이 알러지모델 생쥐의 免疫能에 미치는 影響 및 機轉에 관한 硏究, 대한침구학회지 2005 제22권 3호 p2335.
xiv) Lee et al. The αadrenoceptor mediation of the immunomodulatory effects of electroacupuncture in DNPKLH immunized mice. Neuroscience Letter 423 (2007) 149152.
xv) Lee, H., Lee, J.Y., Kim, Y.J., Kim, S., Yin, C., Khil, J.H., Kwon, K., Choi, S.M., Lee, H., Park, H.J., 2008. Acupuncture for symptom management of rheumatoid arthritis: a pilot study. Clin. Rheumatol. 27, 641 645.
xvi) Wang, R., Jiang, C., Lei, Z., Yin, K., 2007. The role of different therapeutic courses in treating 47 cases of rheumatoid arthritis with acupuncture. J. Tradit. Chin. Med. 27, 103 105.
xvii) Yim, Y.K., Lee, H., Hong, K.E., Kim, Y.I., Lee, B.R., Son, C.G., Kim, J.E., 2007. Electroacupuncture at acupoint ST36 reduces inflammation and regulates immune activity in CollagenInduced Arthritic Mice. Evid. Based Complement. Alternat. Med. 4, 51 57.
xviii) Y. Liu, X. Liu, S. Bai, L. Mu, Q. Kong, B. Sun, D. Wang, J. Wang, S. Shu, G. Wang, H. Li. The effect of electroacupuncture on T cell responses in rats with experimental autoimmune encephalitis, Journal of Neuroimmunology 220. 2010. 25 33.
xix) Jan Kowalski. 1997. Effect of enkephalins and endorphins on cytotoxic activity of natural killer cells and macrophages/monocytes in mice. European Journal of Pharmacology. 326, 251255.
xx) M. Schedlowski, A. Falk, A. Rohne, T. Wagner, R. Jacobs, U. Tewes, R. Schmidt. 1993. Catecholamines induce alterations of distribution and activity of human natural killer(NK) cells. Vol.13, No.5.