항암제의 종류

소개

항암제의 종류에 관한 레포트입니다.

목차

1. common chemotherapeutic agents
2. ntineoplastic drug (cytotoxic agents) 의 class
3. antineoplastic agents
4. cell cycle level에서 action site
5. hemotherapy의 type
6. celluar level에서 action site
7. taxane R의 mechanisms
8. anti-folate transporter
9. 약의 종류

본문내용

1. common chemotherapeutic agents
1)alkylating agents
-DNA와 interact: substitution, cross-linking reaction, strand breaks
-ex. cisplatin
2)antimetabolites
-cytotoxic effect via similarity in structure or function: 핵산합성과 관련된 효소 억제, incorrect codes를 생산
-ex. methotrexate, pemetrexed, gemcitabine, 5-FU
3)antitumor antibiotics
-streptomyces가 생산하는 antimicrobial coumpounds
-핵산의 구조와 기능에 영향 by intercalation btw base pairs(doxorubicin), DNA strand fragmentation(bleomycin), cross-linking DNA(mitomycin)

<중 략>

9. 약의 종류
①alkylating agents
1)nitrogen mustards: mechlorethamine, melphalan, cyclophosphamide, ifosfamide, chlorambucil,
-adverse effect: immunosuppressive, teratogenic, carcinogenic
2)nitrosoureas: carmustine, lomustine, semustine, streptozocin,
3)alkyl sulfonates: busulfan
4)ethylenimine: thiotepa
5)triazenes: dacarbazine
②antimetabolites
1)folate antagonist: MTX
2)purine analogues: 6-thioguanine, 6-mercaptopurine, fludarabine, pentostatin, claribine
3)pyrimidine analogues: cytarabine, 5-FU ③antibiotics

참고자료

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