제2형 당뇨병환자에서 대사증후군 동반 여부에 따른 아디포넥틴의 특징 (Adiponectin Concentrations in Type 2 Diabetic Patients with or without Metabolic Syndrome)

서지정보

· 발행기관 : 대한당뇨병학회
· 수록지 정보 : Diabetes and Metabolism Journal / 32권 / 3호 / 224 ~ 235페이지
· 저자명 : 박자영, 김자원, 김지민, 한영, 박수경, 목지영, 박미경, 이혜정, 김덕규

초록

Background: Adipocytes produce several adipokines that modulate insulin action as well as glucose and lipid metabolism. The aim of this study was to evaluate the relationship between serum adiponectin concentrations and metabolic syndrome(MS) in patients with type 2 diabetes mellitus. Methods: This study included 127 type 2 diabetic patients(males 63, females 64). The subjects were divided into two groups as with or without metabolic syndrome(MS(+) or MS(-)). The MS was diagnosed by International Diabetes Federation. Serum adiponectin, leptin, fasting plasma insulin, glucose, glycated hemoglobin, lipid profile, white blood corpuscle(WBC), aspartate aminotransferase(AST), alanine aminotransferase(ALT), uric acid and C-reactive protein(CRP) were examined.Results: Serum adiponectin concentrations were significantly lower in MS(+) than MS(-)(4.8 ± 2.4 μg/mL vs 7.6 ± 5.8 μg/mL, 7.6 ± 3.7 μg/mL vs 11.5 ± 7.2 μg/mL, P < 0.05 in males and females). After adjustment for age and body mass index(BMI), in MS(+), the serum levels of adiponectin correlated positively with high density lipoprotein - cholesterol(HDL-C) and negatively with height, body weight, ALT and CRP. In MS(-), the serum levels of adiponectin correlated positively with HDL-C and negatively with diastolic blood pressure(DBP), triglyceride and CRP. By multiple regression analysis, no parameters were independently correlated with serum adiponectin concentrations in MS(+), while DBP and HDL-C were independently related to serum adiponectin concentrations in MS(-). Conclusion: Serum adiponectin concentrations were lower in type 2 diabetic patients with MS than without MS. There were no significant parameters related to decrease serum adiponectin concentrations in MS. But further study is needed to confirm this result.(KOREAN DIABETES J 32:224-235, 2008)

영어초록

Background: Adipocytes produce several adipokines that modulate insulin action as well as glucose and lipid metabolism. The aim of this study was to evaluate the relationship between serum adiponectin concentrations and metabolic syndrome(MS) in patients with type 2 diabetes mellitus. Methods: This study included 127 type 2 diabetic patients(males 63, females 64). The subjects were divided into two groups as with or without metabolic syndrome(MS(+) or MS(-)). The MS was diagnosed by International Diabetes Federation. Serum adiponectin, leptin, fasting plasma insulin, glucose, glycated hemoglobin, lipid profile, white blood corpuscle(WBC), aspartate aminotransferase(AST), alanine aminotransferase(ALT), uric acid and C-reactive protein(CRP) were examined.Results: Serum adiponectin concentrations were significantly lower in MS(+) than MS(-)(4.8 ± 2.4 μg/mL vs 7.6 ± 5.8 μg/mL, 7.6 ± 3.7 μg/mL vs 11.5 ± 7.2 μg/mL, P < 0.05 in males and females). After adjustment for age and body mass index(BMI), in MS(+), the serum levels of adiponectin correlated positively with high density lipoprotein - cholesterol(HDL-C) and negatively with height, body weight, ALT and CRP. In MS(-), the serum levels of adiponectin correlated positively with HDL-C and negatively with diastolic blood pressure(DBP), triglyceride and CRP. By multiple regression analysis, no parameters were independently correlated with serum adiponectin concentrations in MS(+), while DBP and HDL-C were independently related to serum adiponectin concentrations in MS(-). Conclusion: Serum adiponectin concentrations were lower in type 2 diabetic patients with MS than without MS. There were no significant parameters related to decrease serum adiponectin concentrations in MS. But further study is needed to confirm this result.(KOREAN DIABETES J 32:224-235, 2008)

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