카드뮴중독 시 쥐신장의 인산염 이동계의 변화 (Effect of Cadmium Intoxication on Renal Phosphate Transport System in Rats)

서지정보

· 발행기관 : 고신대학교(의대) 고신대학교 의과대학 학술지
· 수록지 정보 : 고신대학교 의과대학 학술지 / 7권 / 1호 / 15 ~ 24페이지
· 저자명 : 안도환, 박양생

초록

-Abstract- Effect of cadmium intoxication on the renal cortical phosphate transport system was studied in adult Sprague-Dawley male rats. Subcutaneous injections of CdCl₂ at a dose of 2 mg Cd/kg body weight per day for 2 weeks induced marked polyuria, glycosuria, proteinuria and phosphaturia, which are the characteristics of chronic cadmium intoxication. In the renal cortical brush-border membrane vesicles prepared from cadmium-intoxicated rats, the Na⁺-dependent phosphate uptake was markedly attenuated, whereas the Na⁺-independent uptake was not apparently altered.
These results indicate that cadmium intoxication impairs the Na⁺-dependent phosphate cotransport system in the brush-border membrane of renal proximal tubular cells, which leads to phosphaturia in intact animals.

영어초록

-Abstract- Effect of cadmium intoxication on the renal cortical phosphate transport system was studied in adult Sprague-Dawley male rats. Subcutaneous injections of CdCl₂ at a dose of 2 mg Cd/kg body weight per day for 2 weeks induced marked polyuria, glycosuria, proteinuria and phosphaturia, which are the characteristics of chronic cadmium intoxication. In the renal cortical brush-border membrane vesicles prepared from cadmium-intoxicated rats, the Na⁺-dependent phosphate uptake was markedly attenuated, whereas the Na⁺-independent uptake was not apparently altered.
These results indicate that cadmium intoxication impairs the Na⁺-dependent phosphate cotransport system in the brush-border membrane of renal proximal tubular cells, which leads to phosphaturia in intact animals.

참고자료

· 없음