대장내시경 정결액으로서 sulfate free polyethylene glycol 용액과 기존 polyethylene glycol 용액의 전향적 비교 (Sulfate free polyethylene glycol versus standard polyethylene glycol for colonoscopy preparation: a prospective, randomized, investigator-blinded comparison)

서지정보

· 발행기관 : 대한내과학회
· 수록지 정보 : 대한내과학회지 / 74권 / 1호 / 30 ~ 36페이지
· 저자명 : 김정호, 변정식, 박상현, 류진경, 김병규, 정준원, 최귀숙, 예병덕, 명승재, 양석균, 김진호

초록

Background/Aims : Although polyethylene glycol (PEG) solution is safe and effective for bowel preparation for colonoscopy, its salty taste as well as the required large volume limits its use. Sulfate free PEG (SF-PEG) solution was developed to reduce the salty taste by removing the sodium sulfate. The aim of this study was to compare the SF-PEG solution with the standard PEG solution in regard to the quality of bowel preparation, the degree of patients’ satisfaction and the side effects in Korean patients.
Methods : From July through September in 2006, 100 patients who underwent colonoscopic polypectomy were prospectively enrolled. They were randomly assigned to receive either PEG or SF-PEG solution. The quality of bowel preparation was assessed by one colonoscopist who was blinded with regard to the type of preparation used. Detailed questionnaires were used to assess the patients’ tolerance and satisfaction. The serum biochemical parameters were measured before and after bowel cleansing.
Results : The numbers of patients whose quality of bowel preparation was excellent, good, fair and poor were 2, 43, 5 and 0 in PEG group, while this was 0, 41, 9 and 0 in SF-PEG group, respectively (p=0.118). The side effects were not different between the groups. The visual analog scale score of the patients’ satisfaction was 6.4±2.4 in the PEG group and 5.8±2.8 in the SF-PEG group (p=0.237). The changes of serum biochemical parameters were also not different.
Conclusions : The SF-PEG solution shows similar effectiveness and safety for bowel preparation for colonoscopy when compared to the standard PEG solution. The SF-PEG solution is a good solution to use for colonoscopy preparation. (Korean J Med 74:30-36, 2008)

영어초록

Background/Aims : Although polyethylene glycol (PEG) solution is safe and effective for bowel preparation for colonoscopy, its salty taste as well as the required large volume limits its use. Sulfate free PEG (SF-PEG) solution was developed to reduce the salty taste by removing the sodium sulfate. The aim of this study was to compare the SF-PEG solution with the standard PEG solution in regard to the quality of bowel preparation, the degree of patients’ satisfaction and the side effects in Korean patients.
Methods : From July through September in 2006, 100 patients who underwent colonoscopic polypectomy were prospectively enrolled. They were randomly assigned to receive either PEG or SF-PEG solution. The quality of bowel preparation was assessed by one colonoscopist who was blinded with regard to the type of preparation used. Detailed questionnaires were used to assess the patients’ tolerance and satisfaction. The serum biochemical parameters were measured before and after bowel cleansing.
Results : The numbers of patients whose quality of bowel preparation was excellent, good, fair and poor were 2, 43, 5 and 0 in PEG group, while this was 0, 41, 9 and 0 in SF-PEG group, respectively (p=0.118). The side effects were not different between the groups. The visual analog scale score of the patients’ satisfaction was 6.4±2.4 in the PEG group and 5.8±2.8 in the SF-PEG group (p=0.237). The changes of serum biochemical parameters were also not different.
Conclusions : The SF-PEG solution shows similar effectiveness and safety for bowel preparation for colonoscopy when compared to the standard PEG solution. The SF-PEG solution is a good solution to use for colonoscopy preparation. (Korean J Med 74:30-36, 2008)

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