네트워크약리학을 이용한 생강 활성성분 유래 잠재 타겟 효능 예측 (Prediction of potential targets efficacy derived from ginger active ingredients using network pharmacology)

서지정보

· 발행기관 : 한약정보연구회
· 수록지 정보 : 한약정보연구회지(韓藥情報硏究會誌) / 8권 / 2호 / 255 ~ 266페이지
· 저자명 : 이아영, 이준, 천진미

초록

Ginger (Zingiber officinale Rosc.) has widely used for the digestive in Korea and is the most popular food spices with a uniquely pungent flavor. Many compounds have been isolated in ginger, such as gingerols, steroids, monoterpenoids, etc. Many studies have reported the bioactivity of ginger extracts and active compounds in ginger such as antioxidant, anti-inflammatory, anti-cancer, and effect on the cardiovascular systems. However, the pharmacological effects of ginger between multiple-compounds and multiple-target were not reported yet. So, we confirmed the holistic pharmacological effect of ginger using a network pharmacology approach. We screened through six compounds (6-gingerol, 6-shogaol, dihydrocapsaicin, poriferastan-3β-ol, β-sitosterol, and stigmasterol) with ADME screening in the TCMSP database and searched 55 genes linked to six active compounds using the STITCH database. The core potential target genes were TP53, BCL2, MAPK8, HSP90AA1, and CYP7AA1. And Functional analysis of target genes was performed through Annotation, Visualization, and Integrated Discovery (DAVID) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway databases; 64 pathways were searched. Among them, pathways related to infectious disease were found the most. Therefore, this study was demonstrated the multi-component, multi-target, and multi-pathway characteristics of ginger, which were able to predict various efficacy properties for ginger compounds.

영어초록

Ginger (Zingiber officinale Rosc.) has widely used for the digestive in Korea and is the most popular food spices with a uniquely pungent flavor. Many compounds have been isolated in ginger, such as gingerols, steroids, monoterpenoids, etc. Many studies have reported the bioactivity of ginger extracts and active compounds in ginger such as antioxidant, anti-inflammatory, anti-cancer, and effect on the cardiovascular systems. However, the pharmacological effects of ginger between multiple-compounds and multiple-target were not reported yet. So, we confirmed the holistic pharmacological effect of ginger using a network pharmacology approach. We screened through six compounds (6-gingerol, 6-shogaol, dihydrocapsaicin, poriferastan-3β-ol, β-sitosterol, and stigmasterol) with ADME screening in the TCMSP database and searched 55 genes linked to six active compounds using the STITCH database. The core potential target genes were TP53, BCL2, MAPK8, HSP90AA1, and CYP7AA1. And Functional analysis of target genes was performed through Annotation, Visualization, and Integrated Discovery (DAVID) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway databases; 64 pathways were searched. Among them, pathways related to infectious disease were found the most. Therefore, this study was demonstrated the multi-component, multi-target, and multi-pathway characteristics of ginger, which were able to predict various efficacy properties for ginger compounds.

참고자료

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