皂角刺 추출물의 항응혈 활성 (Anticoagulant Activity of Gleditsiae Spina Extract)

서지정보

· 발행기관 : 대한본초학회
· 수록지 정보 : 대한본초학회지 / 25권 / 1호 / 39 ~ 43페이지
· 저자명 : 유지현, 정봉태, 길기정

초록

Objectives : This research was investigated the anticoagulant effect of the Gleditsiae spina extract.
Methods : We researched prothrombin time (PT) assay, activated partial thromboplastin time (APTT) assay in vitro and in vivo using arteriovenous (A-V) shunt rat model and shortening Rat tail bleeding time (BT). A-V shunt and BT were treated with extract of Gleditsiae spina (GS) 400 ㎎/kg for a week.
Results : Bleeding time of Gleditsiae spina extract in vivo had a significant increase as about 1.2 times and thrombus weight of Gleditsiae spina extract had a significant reduction of thrombus weight as 26%. Gleditsiae spina extract represented an effect of anticoagulation by operating on extrinsic pathway factor II, V, VII, X and intrinsic pathway factor Ⅷ, Ⅸ, Ⅹ, Ⅺ, Ⅻ in the coagulation system.
Conclusions : Considering the above mentioned results, it is judged that a Gleditsiae Spina extract has a control effect of thrombus creation.

영어초록

Objectives : This research was investigated the anticoagulant effect of the Gleditsiae spina extract.
Methods : We researched prothrombin time (PT) assay, activated partial thromboplastin time (APTT) assay in vitro and in vivo using arteriovenous (A-V) shunt rat model and shortening Rat tail bleeding time (BT). A-V shunt and BT were treated with extract of Gleditsiae spina (GS) 400 ㎎/kg for a week.
Results : Bleeding time of Gleditsiae spina extract in vivo had a significant increase as about 1.2 times and thrombus weight of Gleditsiae spina extract had a significant reduction of thrombus weight as 26%. Gleditsiae spina extract represented an effect of anticoagulation by operating on extrinsic pathway factor II, V, VII, X and intrinsic pathway factor Ⅷ, Ⅸ, Ⅹ, Ⅺ, Ⅻ in the coagulation system.
Conclusions : Considering the above mentioned results, it is judged that a Gleditsiae Spina extract has a control effect of thrombus creation.

참고자료

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