Gene Expression Analysis in a Transgenic Mice Expressing NSE-controlled Tau for Alzheimer's Disease Model (Gene Expression Analysis in a Transgenic Mice Expressing NSE-controlled Tau for Alzheimer's Disease Model)

서지정보

· 발행기관 : 한국실험동물학회
· 수록지 정보 : Laboratory Animal Research / 24권 / 4호 / 623 ~ 629페이지
· 저자명 : Jong-Min Woo, So Jung Park, Chuel kyu Kim, Ho-Il Kang, Sun Bo Shim, Su Hae Lee, Ji Soon Sin, 배창준, Sang Seop Kim, Mee Kyung Jang, Byoung-Guk Kim

초록

Alzheimer’s disease is a progressive brain disorder cytopathologically characterized by beta amyloid
plaques consisting of β-amyloid peptides and neurofibrillary tangles consisting of hyperphosphorylated
tau proteins. Transgenic mice expressing NSE/htau23 human wild tau exhibit behavior deficits and the
modulated phosphorylations of tau, GSK3β, and β-catenin. The aim of the present study was to identify
differentially expressed genes during tau pathology in the transgenic mice. These mice display
Alzheimer’s disease features of neurodegeneration and tau hyperphosphorylation. Using Illumina gene
expression beadchips, we compared hippocampal mRNA levels between 6 month-old transgenic mice and
12 month-old transgenic mice. We identified total 28 genes that were expressed greater than 2-fold
higher or lower with a p value <0.05. Of these, 17 genes were up-regulated and 11 genes were downregulated.
Theses gene profiles, therefore, provide novel targets for future molecular and genetic
information on Alzheimer’s disease.

영어초록

Alzheimer’s disease is a progressive brain disorder cytopathologically characterized by beta amyloid
plaques consisting of β-amyloid peptides and neurofibrillary tangles consisting of hyperphosphorylated
tau proteins. Transgenic mice expressing NSE/htau23 human wild tau exhibit behavior deficits and the
modulated phosphorylations of tau, GSK3β, and β-catenin. The aim of the present study was to identify
differentially expressed genes during tau pathology in the transgenic mice. These mice display
Alzheimer’s disease features of neurodegeneration and tau hyperphosphorylation. Using Illumina gene
expression beadchips, we compared hippocampal mRNA levels between 6 month-old transgenic mice and
12 month-old transgenic mice. We identified total 28 genes that were expressed greater than 2-fold
higher or lower with a p value <0.05. Of these, 17 genes were up-regulated and 11 genes were downregulated.
Theses gene profiles, therefore, provide novel targets for future molecular and genetic
information on Alzheimer’s disease.

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