Genotoxicity Safety Evaluation on Gamma-Irradiated Milk and Icecream

서지정보

· 발행기관 : 한국실험동물학회
· 수록지 정보 : Laboratory Animal Research / 25권 / 1호 / 19 ~ 26페이지
· 저자명 : Ji-Sook Ryu, Sun-Kyung Han, Myeong-Su Shin, Bon-Chul Koo, Ji-Hyun Choi, Ju-Woon Lee, Cheorun Jo, Jun-Sang Ham, Wan-Kyu Lee

초록

Gamma irradiation can be applied to the dairy products for eradicating microbial contamination and
making hypo-allergenic foods. However irradiation technology has not been put practical use because of
prejudice against safety of gamma-irradiation. To evaluate the safety of gamma-irradiated dairy product,
genotoxicological test was performed. In vitro mutagenicity of gamma-irradiated milk and ice cream (5,
10 kGy) was evaluated by chromosome aberration test in the presence or absence of metabolizing
activation (S-9 mix). And in vivo safety test was carried out by the micronucleus test in ICR mice. The
gamma-irradiated milk and icecream did not increase chromosome aberration rate at any irradiation
doses or concentration. In micronucleus test, gamma-irradiated milk and icecream did not induce any
significant increase statistically in micronucleated polychromatic erythrocytes (MNPCE) at any irradiation
doses. These results of this study indicate that irradiation on milk and icecream may not induce
genotoxicity and can be an additional safety tool for manufacturing dairy products.

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