Finding informative genes from microarray gene expression data using FIGER-test

서지정보

· 발행기관 : 한국지능시스템학회
· 수록지 정보 : 한국지능시스템학회 논문지 / 17권 / 5호 / 707 ~ 711페이지
· 저자명 : 최경옥, 정환묵

초록

Microarray gene expression data is believed to show the functions of living organism through the gene expression values. We have studied a method to get the informative genes from the microarray gene expression data. There are several ways for this. In recent researches to get more sophisticated and detailed results, it has used the intelligence information theory like fuzzy theory. Some methods are to add fudge factors to the significance test for more refined results.
In this paper, we suggest a method to get informative genes from microarray gene expression data. We combined the difference of means between two groups and the fuzzy membership degree which reflects the variance of the gene expression data. We have called our significance test the Fuzzy Information method for Gene ExpRession data(FIGER). The FIGER calculates FIGER variation ratio and FIGER membership degree to show how strongly each object belongs to the each group and then it results in the significance degree of each gene. The FIGER is focused on the variation and distribution of the data set to adjust the significance level. Our simulation shows that the FIGER-test is an effective and useful significance test.

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