Loss of Integrity: Impairment of the Blood-brain Barrier in Heavy Metal-associated Ischemic Stroke

서지정보

· 발행기관 : 한국독성학회
· 수록지 정보 : 한국독성학회지 / 29권 / 3호 / 157 ~ 164페이지
· 저자명 : 배옥남, Jeong-Hyeon Kim, Hyeong-Min Byun, Eui-Cheol Chung, Han-Young Chung

초록

Although stroke is one of the leading causes of death and disability worldwide, preventive or therapeutic options are still limited. Therefore, a better understanding of the pathophysiological characteristics of this life-threatening disease is urgently needed. The incidence and prevalence of ischemic stroke are increased by exposure to certain types of xenobiotics, including heavy metals, suggesting the possible toxicological contribution of these compounds to the onset or aggravation of stroke. Among the potential targets, we have focused on alterations to cerebral endothelial cells (CECs), which play important roles in maintaining the functional integrity of brain tissue.

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