유기게르마늄(Ge-132 ) 의 랫드와 마우스에 대한 급성경구독성

서지정보

· 발행기관 : 한국식품위생안전성학회
· 수록지 정보 : 한국식품위생안전성학회지 / 12권 / 4호
· 저자명 : 서경원, 이경민, 오미현, 김효정

영어초록

The acute oral toxicity of organogermanium, Ge-132 was evaluated in rats and mice. The changes of body weight and clinical signs were observed for 14 days after the oral administration of Ge-132, from 0.31 g/kg up to 5 g/kg for SD rats and from 1.25 g/kg up to 5 g/kg for ICR mice. No death and toxic effects were observed for 14 days. The body weight of rats was significantly decreased 1 day after the administration in the maximum dosing group, but the decrease of body weight returned to control level 3 days after dosing. No significant changes in body weight were observed in mice. Autopsy revealed no abnormal gross findings related to Ge132. Therefore, Ge-132 has no special toxic effects up to 5 g/kg, and LD_(50) values of Ge-132 are above 5 g/kg in rats and mice.

참고자료

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