Virucidal efficacy of gaseous chlorine dioxide against surface-dried Adenovirus and Herpesvirus

서지정보

ㆍ발행기관 : 한국예방수의학회(구 한국수의공중보건학회) ㆍ수록지정보 : 예방수의학회지 / 46권 / 3호
ㆍ저자명 : Tran Xuan Ngoc Huy, Trang Thi Nguyen, Alisha Wehdnesday Bernardo Reyes, Heejin Kim, WonGi Min, Hu Jang Lee, Suk Kim

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Cell culture and virus stocks preparation
Carrier preparation and gClO2 fumigation
Viruses detachment from the carrier and endpointdilution assay
RESULTS
Virucidal effects of gClO2 against Adenovirus
Virucidal effects of gClO2 against Herpesvirus
DISCUSSION
ACKNOWLEDGEMENTS
CONFLICT OF INTEREST STATEMENT
REFERENCES

영어 초록

Chlorine dioxide (ClO2) has recently emerged as an ideal disinfectant and has shown a wide range of antimicrobial activities in various pathogenic microorganisms. In this study, the virucidal effect of ClO2 at low concentration (0.02 ppm) and higher concentration (0.06 – 0.09 ppm) against Adenovirus and Herpesvirus was evaluated based on the NF T 72-281 and ASTM 1053-11 standard methods at different exposure times. The virus suspension was dried onto the carrier and then exposed to gaseous ClO2 (gClO2) at 22 ± 2∘C. For Adenovirus, exposure at a low concentration of ClO2 at the middle height resulted in the average log10 reduction of 0.95, 2.65, and 5.30 after 1, 3, and 6 h post-exposure (pe), respectively. Moreover, more than 4-log10 reduction was achieved at 4 and 6 h pe with higher concentrations of ClO2. On the other hand, the antiviral activity of gClO2 at the middle height was also effective against Herpesvirus. In particular, at 1 h pe, a less than 4-log10 reduction was observed at all examined concentrations of ClO2, whereas exposure for 3 and 6 h (with low concentration) or 2 h (with higher concentration) inactivated completely viruses attached to the carrier. These results suggested that ClO2 fumigation is a potential alternative method for disinfecting healthcare facilities, high-containment laboratories, and households with a safe concentration for human health.

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