구강편평세포암종의 진행과 관련된 저산소증에 의해 유도되는 MicroRNAs와 예측 대상 mRNAs의 변화
(주)코리아스칼라
- 최초 등록일
- 2016.04.02
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- 2012.04
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서지정보
ㆍ발행기관 : 대한구강악안면병리학회
ㆍ수록지정보 : 대한구강악안면병리학회지 / 36권 / 2호
ㆍ저자명 : 이지혜
목차
Ⅰ. Introduction
Ⅱ. Materials and Methods
Cell culture and treatment
RNA preparation
miRNA expression array
Data analysis and statistics
Target prediction
Ⅲ. Results
miRNA expression profiles in OSCC cells
Identification of predicted gene targets ofdifferentially expressed miRNAs
Ⅳ. Discussion
Ⅴ. References
영어 초록
Tumor cells, especially in a malignant form, proliferate rapidly that blood supply within the tumors becomes limited, leading to a condition of insufficient oxygen supply. Such hypoxic condition is known to impair the viability of cancer cells, but it can also be a factor to facilitate the appearance of cells with a higher degree of malignancy. Indeed, the hypoxic condition created within malignant tumors may contribute to promoting their aggressive behaviors, including tumor invasion and metastasis, and to the development of resistance to various therapeutic modalities such as chemotherapy. Recently, microRNAs, a group of short RNA fragments consisting of 18 to 20 nucleotides, have been shown to participate in regulating genes important for cell survival, differentiation and apoptosis. Since their discovery, modulation of these microRNAs has been a focus of intensive studies with regard to their significance on gene regulation and various aspects of cell biology. In this study, we investigated hypoxia-induced alterations in microRNAs in oral squamous cell carcinoma (OSCC) cells and discussed consequential gene modulation and relevant cellular responses.
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