염 민감성 쥐에서 안지오텐신 Ⅱ가 고혈압 면역 기전에 미치는 영향

서지정보

ㆍ발행기관 : 한국식품영양학회 ㆍ수록지정보 : 한국식품영양학회지 / 36권 / 6호
ㆍ저자명 : 황보미향

목차

서 론
연구대상 및 방법
1. 동물
2. 혈압 측정
3. 유세포 분석
4. 실시간 중합효소연쇄반응
5. 통계적 분석
결과 및 고찰
1. 안지오텐신 Ⅱ 투여가 달 소금 민감성 쥐의 수축기혈압에 미치는 영향
2. 안지오텐신 Ⅱ 투여가 달 소금 민감성 쥐와 달 소금저항성 쥐의 T 도움 17 세포와 T 조절 세포에 미치는 영향
3. 안지오텐신 Ⅱ 투여가 달 소금 민감성 쥐와 달 소금저항성 쥐의 대식세포에 미치는 영향
요약 및 결론
References

영어 초록

Hypertension caused by high-fat and high-salt diets is is a well-known significant risk factor for cardiovascular and cerebrovascular diseases. In this study, to confirm the relationship between hypertension and immune cells, angiotensin (Ang) II was administered to Dahl salt-sensitive (SS) rats and Dahl salt-resistant (SR) rats. Then the expression of immune cells and the proinflammatory cytokines were compared between the SS and SR rats. It was observed that after administration of Ang II (50ng/kg/min) for three weeks, blood pressure was increased in the SS rats, but there was no significant change in the SR rats. In addition, the expression of T helper (Th) cells and Th 17 cells in the spleen and the expression of Th cell Rorγt and regulatory T regulatory (Treg) cells in the peripheral blood mononuclear cells did not show a significant difference between the two experimental groups even after the administration of Ang II.IL-1β expression was significantly increased in the kidney tissue of the SS rats, while there was no significant difference in the IL-6 expression in all the experimental groups. The results of this study suggest that Ang II induces hypertension by stimulating IL-1β secretion from renal macrophage in SS rats.

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