로타바이러스 감염된 Vero 세포에서 Lactobacillus ruminus와 Bifidobacterium longum의 케모카인 변화 분석
(주)코리아스칼라
- 최초 등록일
- 2023.06.19
- 최종 저작일
- 2019.12
- 5페이지/ 어도비 PDF
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서지정보
ㆍ발행기관 : 한국유산균학회
ㆍ수록지정보 : Current Topic in Lactic Acid Bacteria and Probiotics / 5권 / 2호
ㆍ저자명 : 최예진, 신혜순
목차
Abstract
서 론
재료 및 방법
세포주 및 배양 조건
MTT assay
Rotavirus 증식
Plaque assay
Interleukin-8의 분석
Monocyte chemoattractant protein-1의 분석
결과 및 고찰
세포독성 평가
Rotavirus infection 및 titer 결정
유산균 추출물에 의한 chemokine 변화 분석
References
영어 초록
Probiotics, such as Lactobacillus spp. and Bifidobacterium spp. are reported to have the multiple potential health benefits including blocking gastroenteric pathogens, reduce gut permeability, enhancing immune response and anti-viral effects. In this study, we explored whether LR211 and BL205, 206 exert on MCP-1 and IL-8 chemokines responses in rotavirus infected vero cells. And we investigated anti-rotaviral activity of Lactobacillus spp. and Bifidobacterium spp. isolated against rotavirus by plaque assay. As a results, all of them were not toxic to vero cells. Three probiotics, BL205, 206 and LR211, increased release of MCP-1 and IL-8 in Wa rotavirus infected vero cells compared to control. This anti-viral effects of LR211 and BL205, 206 can be explained that they modulate immune response by inducing MCP-1 and IL-8 chemokines.
참고 자료
없음
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