Porphyromonas gingivalis 관련 치주질환과 알츠하이머성 치매 간의 기능적 상관관계 연구
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서지정보
ㆍ발행기관 : 대한구강악안면병리학회
ㆍ수록지정보 : 대한구강악안면병리학회지 / 46권 / 6호
ㆍ저자명 : 부가영, 최대솔, 곽혜원, 전다은, 강수은, 이민서, 박태영, 심현룡, 이지혜
ㆍ저자명 : 부가영, 최대솔, 곽혜원, 전다은, 강수은, 이민서, 박태영, 심현룡, 이지혜
목차
AbstractⅠ. INTRODUCTION
Ⅱ. P. gingivalis-induced gingipain as asignificant molecular player to accelerateAlzheimer’s dementia
1. Gingipain as an important exotoxin derivedfrom P. gingivalis
2. Host system damage induced by gingipains
3. Gingipain as a contributing factor toAlzheimer’s dementia
Ⅲ. Expression of pathophysiologic hallmarksof Alzheimer’s dementia influenced bygingipains
1. The β-amyloid plaques as a representativepathophysiologic hallmark of Alzheimer’sdementia
2. Accumulation of the β-amyloid plaquesfacilitated by gingipains
3. Neurofibrillary tangles and its formationinfluenced by gingipains
4. Clinical trials of gingipain inhibitors to treatAlzheimer’s dementia
Ⅳ. Lipopolysaccharide as a significant riskfactor to accelerate Alzheimer’s dementia
1. Lipopolysaccharide as an importantendotoxin derived from P. gingivalis
2. Cellular mechanisms underlyinglipopolysaccharide-induced microglialdamage linked to Alzheimer’s disease
3. A novel hypothesis of LPS-induced myelindamage as a potential link betweenP. gingivalis-derived lipopolysaccharide andAlzheimer’s dementia
Ⅴ. A relationship between immune evasion ofP. gingivalis and Alzheimer’s dementia
1. Immune evasion of infectious pathogensfrom the host innate immunity
2. Complement system as a target of immuneevasion by bacterial pathogens
3. Immune evasion mechanisms of P. gingivalis
4. Evasion of innate immunity by P. gingivalisand Alzheimer’s dementia
Ⅵ. Conclusion
ACKNOWLEDGMENTS
REFERENCES